| __ | 1. | Columbian Exchange | | A. | Exchange of goods between the Old World and New World |
| __ | 2. | Disease | | B. | An abnormal condition of the body that causes discomfort |
| __ | 3. | Indigo | | C. | The area of North and South America |
| __ | 4. | Monarch | | D. | The area of Europe, Asia, and Africa |
| __ | 5. | New World | | E. | Tropical plan used to make blue dye |
| __ | 6. | Old World | | F. | A disease caused by the variola virus |
| __ | 7. | Original reason for exploratio | | G. | A nation's ruler or leader, usually due to their family |
| __ | 8. | Scurvy | | H. | A sea route to Asia |
| __ | 9. | Skraelings | | I. | A condition sailors faced due to a lack of vitamin C |
| __ | 10. | Smallpox | | J. | Indigenous people of North America and Greendland |
| __ | 11. | Astrolabe | | A. | A device that shows what direction north is |
| __ | 12. | Caravel | | B. | A triangular sail mounted at an angle on the mast of a ship |
| __ | 13. | Expedition | | C. | A sea route north of Canada through the Arctic Ocean. |
| __ | 14. | Exploration | | D. | The process of discovering something new |
| __ | 15. | Lanteen sail | | E. | A tool used to measure the location of a star |
| __ | 16. | Magnetic compass | | F. | A flat piece of wood that controls the direction of the ship |
| __ | 17. | Northwest passage | | G. | A large amount of money or possessions |
| __ | 18. | Rudder | | H. | A large sailing vessel for long journeys |
| __ | 19. | Trade winds | | I. | Winds, or currents, that flow across the Atlantic |
| __ | 20. | Wealth | | J. | A trip made for the purpose of discovery or exploration |