Psychopharmacology Practice Exam - Antipsychotic
  • 1. Which of the following is not an injectible atypical antipsychotic?
A) Zyprexa
B) Geodon
C) Risperdal
D) Prolixin
  • 2. Which of the following is a metabolite of Risperadone?
A) Clozaril
B) Invega
C) Abilify
D) Zyprexa
  • 3. Which of the following is good for symptoms of hostility and suspiciousness
A) Invega
B) Seroquel
C) Zyprexa
D) Abilify
  • 4. Which of the following medications is associated with MASSIVE weight gain?
A) Zyprexa
B) Abilify
C) Seroquel
D) Risperdal
  • 5. Which of the following atypical antipsychotics is associated with the side effect of HEAVY SEDATION?
A) Seroquel
B) Geodon
C) Abilify
D) Risperdal
  • 6. Which of the following is associated with irregular heart rate problems?
A) Clozapine
B) Quetiapine
C) Ziprasidone
D) Olanzapine
  • 7. Which of the following medications DEFINITELY has dose-related EPS? (Specifically, when you don't want patients dosed over 10mg)
A) Paliperidone
B) Risperidone
C) Ziprasidone
D) Aripriprazole
  • 8. Which of the following drugs is associated with Agranulocytosis?
A) Clozaril
B) Geodon
C) Seroquel
D) Risperdal
  • 9. Which of the following acts as both an antagonist of dopaminergic hyperactivity and an agonist of dopaminergic hypoactivity?
A) Paliperidone
B) Ziprasidone
C) Aripiprazole
D) Clozapine
  • 10. Which of the following has the most common side effects related to restlessness and EPS?
A) Quetiapine
B) Paliperidone
C) Risperdone
D) Olazapine
  • 11. Which of the following are associated with prolactin increase?
A) Risperidone and Paliperidone
B) Aripiprazole and Paliperidone
C) Clozapine and Aripiprazole
D) Clozapine and Risperadone
  • 12. When patients have had more than one psychotic episode, it is best for them to continue psychopharmacological treatment for ________ years following remission of their most recent episode of psychotic symptoms.
A) 1
B) 2-5
C) 4-5
D) 1-3
  • 13. After a patient's first psychotic episode, it is suggested that they should continue psychopharmacologic treatment for ____ months following the remission of psychotic symptoms.
A) 6
B) 12
C) 24
D) 18
  • 14. Discontinuation of antipsychotic medication should be gradual and tapered rather than sudden.
A) FALSE
B) TRUE
  • 15. Which of the following is NOT a goal in the psychophmarmacologic treatment of Schizophrenia?
A) Develop more adaptive coping skills
B) Foster patients' medication compliance
C) Prevent relapse into another psychotic episode
D) Minimize side effects of medication
  • 16. When are patients with past episodes of psychosis at greatest risk for relapse?
A) several weeks after discontinuation of medication
B) six months after discontinuation of medication
C) directly after discontinuation of medication
D) one year after discontinuation of medication
  • 17. Which of the following would be a first choice for psychopharmacologic treatment for Schizophrenia?
A) Clozaril
B) Symmetrel
C) Artane
D) Thorazine
  • 18. Which of the following is FALSE about atypical neuroleptics?
A) tardive dyskinesia more common
B) increased effectiveness for positive, negative, and disorganized symptoms
C) weight gain more common
D) enhanced efficacy in treatment-resistant patients
  • 19. Which is the standard antipsychotic drug by which newer drugs are compared for efficacy in reducing symptoms?
A) Clozapine
B) Haloperiodol
C) Prochlorperazine
D) Risperidone
  • 20. All of the following drugs interact with neuroleptics to cause increased sedation EXCEPT
A) Stimulants
B) Anxiolitics
C) Anticonvulsants
D) Alcohol
  • 21. All of the following can interact with neuroleptic drugs and create the risk for hypotension EXCEPT
A) Alcohol
B) Merperidine
C) Halperiodol
D) Beta blockers
  • 22. With neuroleptics, all of the following substances INDUCE the action of the P450 system (to lower blood levels of the neuroleptic) EXCEPT
A) Nicotine
B) Anticonvulsants
C) Beta blockers
D) Antacids
  • 23. With neuroleptics, all of the following substances INHIBIT the action of the P450 system (to raise blood levels of the neuroleptic) EXCEPT
A) Beta blockers
B) SSRIs
C) Alcohol
D) Tricyclic antidepressants
  • 24. Immediate discontinuation of neuroleptic medication after the development of tardive dyskinesia symptoms can halt further development of the disorder.
A) TRUE
B) FALSE
  • 25. All of the following are associated with greater risk for Tardive Dyskenesia (while on neuroleptic medication) EXCEPT
A) Alcohol use
B) Tobacco use
C) Drug holidays
D) Male gender
  • 26. The longer a person is on a neuroleptic medication, the greater the risk for the development of Tardive Dyskinesia.
A) TRUE
B) FALSE
  • 27. Which of the following is true?
A) All antipsychotic drugs but Clozapine present a significant risk for the development of tardive dyskinesia.
B) The more frequent the dose of the antipsychotic medication, the greater the risk for the development of tardive dyskinesia.
C) High potency antipsychotic drugs present greater risk for the development of tardive dyskinesia.
D) Classic antipsychotic medications present less risk for the development of tardive dyskinesia than atypical antipsychotic medications.
  • 28. Which of the following is not an EPS (extrapyramidal side effect)?
A) Ataxia
B) Akathesia
C) Acute dystonia
D) Akinesia
  • 29. High fever, catatonia, stupor, and unstable blood pressure are side effects of Phenothiazines associated with
A) Agranulocytosis
B) Postural hypotension
C) Gynecomastia
D) Neuroleptic Malignant Syndrome
  • 30. Piperideines are potent phenothiazines and piperazines are weak phenothiazines.
A) TRUE
B) FALSE
  • 31. The relationship between therapeutic benefit and side effect profiles of neuroleptic drugs depend on actions at different receptor subtypes within different brain pathways.
A) TRUE
B) FALSE
  • 32. Neuroleptic drugs
A) agonize the normal dopamine-mediated inhibition of prolactin release.
B) antagonize the normal dopamine-mediated inhibition of prolactin release.
C) block D2 receptors in the pituitary gland and decrease prolactin secretion.
D) block D2 receptors in the pituitary gland and inhibit prolactin secretion.
  • 33. All of the following provide evidence for the actions of neuroleptics on dopamine EXCEPT
A) hungry hungry hippos
B) receptor binding and DA turnover
C) neuroendocrine changes
D) molecular structure
  • 34. _______________ are currently the largest and most commonly used class of antipsychotics.
A) Thioxanthenenes
B) Butyrophenones
C) Phenothiazines
D) Sleepykoaladones
  • 35. _________ antipsychotics should be used in _____ doses and have ________ rates of EPS.
A) Weak; high; higher
B) Potent; low; lower
C) Potent; low; higher
D) Weak; high; lower
  • 36. All of the following are associated with less disability and better responses to antipsychotic medication EXCEPT:
A) Delusions
B) Anhedonia
C) Hallucinations
D) Formal thought disorder
  • 37. In patients who have psychotic features, which of the following are important rule-outs for differential diagnoses?
A) Neurological disorders
B) Autoimmune diseases
C) Endocrine disorders
D) All of the above
E) Metabolic disorders
  • 38. Which of the following can produce psychotic symptoms during intoxication or withdrawal?
A) Opioids
B) All of the above
C) Stimulants
D) Hallucinogens
E) Alcohol
  • 39. Antipsychotics can be used for the treatment of Bipolar disorder, MDD, Parkinson's disease, Developmental disorders, and Tourette's disorder.
A) TRUE
B) FALSE
  • 40. Higher rates of permanent disability are associated with
A) disorganized symptoms of Schizophrenia.
B) negative symptoms of Schizophrenia.
C) All of the above.
D) positive symptoms of Schizophrenia.
  • 41. Effective antipsychotics interfere with dopamine transmission by
A) blocking post-synaptic dopamine receptors and/or inhibiting dopamine release.
B) blocking pre-synaptic dopamine receptors and/or inhibiting dopamine release.
C) blocking post-synaptic dopamine receptors and/or inhibiting dopamine reuptake.
D) blocking pre-synaptic dopamine receptors and/or inhibiting dopamine reuptake.
  • 42. Extrapyramidal side effects commonly occur with the use of neuroleptic medications because
A) the drug increases the normal dopamine-mediated activity in the striatum, which then enhances the cholinergic response that is normally inhibited by dopamine.
B) the drug reduces the normal dopamine-mediated activity in the striatum, which then enhances the cholinergic response that is normally inhibited by dopamine.
C) the drug reduces the normal dopamine-mediated activity in the striatum, which then reduces the cholinergic response that is normally inhibited by dopamine.
D) the drug increases the normal dopamine-mediated activity in the striatum, which then reduces the cholinergic response that is normally inhibited by dopamine.
  • 43. Which of the following does NOT occur as a result of neuroleptics antagonizing D2L autoreceptors?
A) increased rates of synthesis
B) increased release of dopamine
C) increased rates of firing
D) increased tap dancing
  • 44. Postural hypotension occurs frequently in
A) thioxanthenes
B) piperideines
C) piperazines
D) aliphatics
  • 45. Increases in prolactin secretion due to use of neuroleptic medication can result in
A) genecomastia
B) all of the above
C) menstrual irregularity
D) galactorrhea
  • 46. Which of the following is NOT an anticholinergic medication used to treat EPS (caused by neuroleptic use)?
A) Inapsine (droperiodol)
B) Symmetrel (amantadine)
C) Benadryl (diphenhydramine)
D) Cogentin (benztropine)
E) Artane (trihexphenidyl)
  • 47. Some atypical antipsychotics are selective receptor antagonists and others antagonize multiple receptor systems.
A) FALSE
B) TRUE
  • 48. Some suggestions for why newer antipsychotics have greater effectiveness in treating negative symptoms include ALL of the following EXCEPT
A) polypharmacy
B) comparative lack of EPS
C) superior impact on positive symptoms
D) actual impact at the biological level
  • 49. Which medication is especially good for refractory patients and those with severe psychosis?
A) Invega
B) Haldol
C) Clozaril
D) Abilify
  • 50. Which of the following drugs is chemically unrelated to any other antipsychotic?
A) Clorazil
B) Risperdal
C) Geodon
D) Seroquel
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